Research and Innovations
Our neonatologists, pediatricians, and fellows are engaged in basic science and clinic research projects, with the goal of improving outcomes for premature babies. The neonatology research team at UAMS supports several projects including, but not limited to, the following topics:
- Bronchopulmonary dysplasia/chronic lung disease of prematurity
- Necrotizing enterocolitis
- Patent ductus arteriosus
- Opioid withdrawal
- Neonatal resuscitation
- Quality improvements within the NICU
- Long-term outcomes in preterm infants
UAMS collaborates with Arkansas Children’s and other institutions across the United States and internationally, and participates in multicenter clinical trials; through this work we are able to offer our NICU patients the most advanced technology and evidence-based approaches to care.
In addition, our research faculty are actively involved in training and mentoring junior investigators, fellow physicians, pediatric residents, and students.
Current Studies
- The Connection Study: A randomized, double blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of IBP-9414 in premature infants 500-1500g birth weight in the prevention of necrotizing enterocolitis (NEC)
- Pragmatic, Randomized, Blinded Trial to Shorten Pharmacologic Treatment of Newborns with Neonatal Opioid Withdrawal Syndrome (NOWS)
- A Partially-Blind, Randomized, Controlled, Parallel-Group Dose Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact (SF-RI 1 surfactant for inhalation combined with a dedicated drug delivery system) in Preterm Infants at Risk of Worsening Respiratory Distress Syndrome
- A Phase 1b, Randomized, Blinded, Dose-Determined Study Evaluating the Safety and Tolerability Profile of Intervention with AT-100 (rhSP-D) in Preterm Neonates at High Risk for the Development of Bronchopulmonary Dysplasia (BPD)
- POLAR Trial: Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants at Birth
- DIVA Trial: The Diaphragmatic Initiated Ventilatory Assist
- PIVOTAL Trial: Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low weight Infants
- SILDI-SAFE Trial: Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary Dysplasia
Contact Us
For more information about our clinical research, please contact our research team at: NICUResearch@uams.edu, (501) 296-1389