Matthew G. Deneke, M.D. Gastroenterologist
Primary Appointment Location
Gastroenterology Clinic
4110 Outpatient Circle
Outpatient Center
Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients
Overview
- Areas of Expertise
- Organ Transplantation
- Digestive Health
- Accepting New Patients
- Yes
- Patient Type
- Adults
- Language
- English

About Dr. Deneke
Clinical Biography
Dr. Deneke initially joined the faculty at UAMS in 2005 as an Assistant Professor of Medicine for the Division of General Internal Medicine. While faculty, he served as Medical Director of the ambulatory teaching clinic for internal medicine residents and as the Associate Practice Director for UAMS Internal Medicine Clinics. After five years, Dr. Deneke stepped down as faculty to pursue additional training in gastroenterology and hepatology. He rejoined the UAMS faculty in the Division of Gastroenterology and Hepatology in 2014. He is currently the program director for the UAMS Gastroenterology Fellowship Program. He is a part of the UAMS Liver Transplant team and also operates the UAMS Fatty Liver Disease Clinic.
His clinical interests include liver disease, with a focus on nonalcoholic fatty liver disease, complications of liver disease, and liver transplantation.
Dr. Deneke's Academic Background
Faculty Appointments
- Department of Internal Medicine — Division of Gastroenterology and Hepatology
- Assistant Professor
Education and Training
- Medical School
- University of Arkansas for Medical Sciences
- Residency
- University of Alabama at Birmingham
- Fellowship
- University of Arkansas for Medical Sciences
- Fellowship
- Mayo Clinic
Transplant Hepatology
Professional Certifications
- American Board of Internal Medicine — Internal Medicine
Dr. Deneke's Research
UAMS Research Profile
Each UAMS faculty member has a research profile page that includes biographical and contact information, a list of their most recent grant activity and a list of their PubMed publications.
Conditions Diagnosed or Treated by Dr. Deneke
UAMS Health providers care for a broad range of conditions, some of which may not be listed below.
Medical Treatments and Procedures Performed or Prescribed by Dr. Deneke
UAMS Health providers perform and prescribe a broad range of treatments and procedures, some of which may not be listed below.
Dr. Deneke's Areas of Expertise

Organ Transplantation
Organ transplants are often life-saving treatments for conditions where an organ has failed or is no longer functioning properly.

Digestive Health
With highly skilled and trained specialists and the latest technology, UAMS Health's digestive health services are the most complete in the state.
Locations Where Dr. Deneke Practices

Gastroenterology Clinic , Primary Location
4110 Outpatient Circle
Outpatient Center
Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients

Liver Transplant Clinic at the UAMS Medical Center
4110 Outpatient Circle
Outpatient Center
Suite 3150
Little Rock, AR 72205
- Appointment Phone Number
- 800-552-8026
New and Returning Patients
Comment
I spoke to me as one professional to another and they did not either assume I would not understand nor talk down to me I appreciate that in a provider.
Date
Nov 07, 2024Comment
The nurse was extremely helpful and explained everything and took care of all the issues I had. And then the doctors explained everything in a manner I could understand it and listened to what I had to say and answered all my questions and came up with a plan of care, good care.
Date
Sep 16, 2024Comment
Well, honestly, I live over 2 hours away from doctor and my appointment was at 1:30 and I did not go back till after 3:00. It makes it hard when I have to drive a good ways to be kept waiting that long. I understand things come up, however, maybe not schedule so many people on same day. Just my opinion.
Date
Sep 16, 2024Comment
I meant to press 10. I would recommend Dr. Deneke to anyone. Thank you.
Date
Sep 10, 2024Comment
The nurses and staff at UAMS transplant clinic are more like family than medical workers. They all know you by first and last name before you check in, they remember your situation with your family and personal events, they ask about them and they follow up! A lovely group of people. They also go out of their way to accommodate you if you're early..., or late.
Date
Aug 23, 2024Comment
Good in all respects. Dr. Deneke is the best!
Date
Aug 22, 2024Comment
When I went in to check in, there was a woman replacing the receptionist because she was on lunch and she told me she checked me in and she did not. And so it made me a little late for my appointment and I was not happy.
Date
Aug 20, 2024Comment
The service was very great
Date
Aug 13, 2024Comment
Dr. Deneke has compassion and understanding. I always feel comfortable asking questions. He was recommended to me by Dr [NAME] from the [OTHER FACILITY]
Date
Jul 25, 2024Comment
Dr Deneke was very knowledgeable about my history. He listened carefully & he & I together constructed a plan for me. He is an asset to the medical field. I could tell he has my best interest.
Date
Jul 25, 2024