Matthew G. Deneke, M.D. Gastroenterologist
Primary Appointment Location
Gastroenterology Clinic
4110 Outpatient Circle
Outpatient Center
Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients
Overview
- Areas of Expertise
- Organ Transplantation
- Digestive Health
- Accepting New Patients
- Yes
- Patient Type
- Adults
- Language
- English
About Dr. Deneke
Clinical Biography
Dr. Deneke initially joined the faculty at UAMS in 2005 as an Assistant Professor of Medicine for the Division of General Internal Medicine. While faculty, he served as Medical Director of the ambulatory teaching clinic for internal medicine residents and as the Associate Practice Director for UAMS Internal Medicine Clinics. After five years, Dr. Deneke stepped down as faculty to pursue additional training in gastroenterology and hepatology. He rejoined the UAMS faculty in the Division of Gastroenterology and Hepatology in 2014. He is currently the program director for the UAMS Gastroenterology Fellowship Program. He is a part of the UAMS Liver Transplant team and also operates the UAMS Fatty Liver Disease Clinic.
His clinical interests include liver disease, with a focus on nonalcoholic fatty liver disease, complications of liver disease, and liver transplantation.
Dr. Deneke's Academic Background
Faculty Appointments
- Department of Internal Medicine — Division of Gastroenterology and Hepatology
- Assistant Professor
Education and Training
- Medical School
- University of Arkansas for Medical Sciences
- Residency
- University of Alabama at Birmingham
- Fellowship
- University of Arkansas for Medical Sciences
- Fellowship
- Mayo Clinic
Transplant Hepatology
Professional Certifications
- American Board of Internal Medicine — Internal Medicine
Dr. Deneke's Research
UAMS Research Profile
Each UAMS faculty member has a research profile page that includes biographical and contact information, a list of their most recent grant activity and a list of their PubMed publications.
Conditions Diagnosed or Treated by Dr. Deneke
UAMS Health providers care for a broad range of conditions, some of which may not be listed below.
Medical Treatments and Procedures Performed or Prescribed by Dr. Deneke
UAMS Health providers perform and prescribe a broad range of treatments and procedures, some of which may not be listed below.
Dr. Deneke's Areas of Expertise
Organ Transplantation
Organ transplants are often life-saving treatments for conditions where an organ has failed or is no longer functioning properly.
Digestive Health
With highly skilled and trained specialists and the latest technology, UAMS Health's digestive health services are the most complete in the state.
Locations Where Dr. Deneke Practices
Gastroenterology Clinic , Primary Location
4110 Outpatient Circle
Outpatient Center
Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients
Liver Transplant Clinic at the UAMS Medical Center
4110 Outpatient Circle
Outpatient Center
Suite 3150
Little Rock, AR 72205
- Appointment Phone Number
- 800-552-8026
New and Returning Patients
Comment
Truly enjoy both of current Doctors and assistants
Date
Feb 27, 2026Comment
This was just a 6 month checkup ( that took 7 additional months) and I am doing very well -no problems at all but felt rushed
Date
Feb 13, 2026Comment
It was good
Date
Feb 11, 2026Comment
Good
Date
Feb 10, 2026Comment
Dr. Deneke was detailed, and listened carefully to what I said. I have never had a doctor go over in detail the medical history they asked me to fill out. But. Dr. Deneke went over everything. I felt as if he really listened to me. He asked excellent questions. I really liked him!
Date
Feb 10, 2026Comment
Awesome communications
Date
Jan 20, 2026Comment
I have been seeing Matthew Deneke for 10 years now and could not be more pleased with the care provided or how well he listens to me
Date
Nov 16, 2025Comment
This doesn't really cover specialists for a checkup.
Date
Nov 13, 2025Comment
Love my doctors
Date
Nov 11, 2025Comment
Excellent
Date
Oct 21, 2025