Matthew G. Deneke, M.D. Gastroenterologist
Primary Appointment Location
Gastroenterology Clinic
4110 Outpatient Circle
Outpatient Center
Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients
Overview
- Areas of Expertise
- Organ Transplantation
- Digestive Health
- Accepting New Patients
- Yes
- Patient Type
- Adults
- Language
- English
About Dr. Deneke
Clinical Biography
Dr. Deneke initially joined the faculty at UAMS in 2005 as an Assistant Professor of Medicine for the Division of General Internal Medicine. While faculty, he served as Medical Director of the ambulatory teaching clinic for internal medicine residents and as the Associate Practice Director for UAMS Internal Medicine Clinics. After five years, Dr. Deneke stepped down as faculty to pursue additional training in gastroenterology and hepatology. He rejoined the UAMS faculty in the Division of Gastroenterology and Hepatology in 2014. He is currently the program director for the UAMS Gastroenterology Fellowship Program. He is a part of the UAMS Liver Transplant team and also operates the UAMS Fatty Liver Disease Clinic.
His clinical interests include liver disease, with a focus on nonalcoholic fatty liver disease, complications of liver disease, and liver transplantation.
Dr. Deneke's Academic Background
Faculty Appointments
- Department of Internal Medicine — Division of Gastroenterology and Hepatology
- Assistant Professor
Education and Training
- Medical School
- University of Arkansas for Medical Sciences
- Residency
- University of Alabama at Birmingham
- Fellowship
- University of Arkansas for Medical Sciences
- Fellowship
- Mayo Clinic
Transplant Hepatology
Professional Certifications
- American Board of Internal Medicine — Internal Medicine
Dr. Deneke's Research
UAMS Research Profile
Each UAMS faculty member has a research profile page that includes biographical and contact information, a list of their most recent grant activity and a list of their PubMed publications.
Conditions Diagnosed or Treated by Dr. Deneke
UAMS Health providers care for a broad range of conditions, some of which may not be listed below.
Medical Treatments and Procedures Performed or Prescribed by Dr. Deneke
UAMS Health providers perform and prescribe a broad range of treatments and procedures, some of which may not be listed below.
Dr. Deneke's Areas of Expertise
Organ Transplantation
Organ transplants are often life-saving treatments for conditions where an organ has failed or is no longer functioning properly.
Digestive Health
With highly skilled and trained specialists and the latest technology, UAMS Health's digestive health services are the most complete in the state.
Locations Where Dr. Deneke Practices
Gastroenterology Clinic , Primary Location
4110 Outpatient Circle
Outpatient Center
Suite 3160
Little Rock, AR 72205
- Appointment Phone Number
- 501-603-1900
New and Returning Patients
Liver Transplant Clinic at the UAMS Medical Center
4110 Outpatient Circle
Outpatient Center
Suite 3150
Little Rock, AR 72205
- Appointment Phone Number
- 800-552-8026
New and Returning Patients
Comment
Awesome communications
Date
Jan 20, 2026Comment
I have been seeing Matthew Deneke for 10 years now and could not be more pleased with the care provided or how well he listens to me
Date
Nov 16, 2025Comment
This doesn't really cover specialists for a checkup.
Date
Nov 13, 2025Comment
Love my doctors
Date
Nov 11, 2025Comment
Excellent
Date
Oct 21, 2025Comment
Detailed
Date
Oct 16, 2025Comment
Everything went well, we waited awhile to initially be seen but I was happy with the info and results the Dr. Provided
Date
Oct 15, 2025Comment
Would recommend this practice with the caveat of the extremely long wait time.My appointment was on a Monday and I understand that this is a busy day, but my appointment time was 2:15 and I left the clinic after 4;30. In fact, the Fellow left the clinic before I did. So, my over two hours in clinic involved 5-10 minutes with the Fellow and less than 5 minutes with the Doctor. I did schedule another appointment, and I requested a day other that Monday or Wednesday--another busy day I was told by the check-out person. However, it appears the Fellow or Doctor, or both, only have Monday appointments. This seemed odd to me and the check-out person.
Date
Sep 11, 2025Comment
Fair
Date
Sep 03, 2025Comment
[NAME] APRN goes out of her way to help. Smart and very capable. She is genuinely concerned and I truly appreciate all of her help. Dr Deneke is awesome. Love my team!
Date
Aug 29, 2025