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  1. UAMS Health
  2. Conditions
  3. Amyotrophic Lateral Sclerosis (ALS)

Condition: Amyotrophic Lateral Sclerosis (ALS)

Also called: Lou Gehrig's Disease

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord. These neurons transmit messages from your brain and spinal cord to your voluntary muscles - the ones you can control, like in your arms and legs. At first, this causes mild muscle problems. Some people notice:

  • Trouble walking or running
  • Trouble writing
  • Speech problems

Eventually, you lose your strength and cannot move. When muscles in your chest fail, you cannot breathe. A breathing machine can help, but most people with ALS die from respiratory failure.

The disease usually strikes between age 40 and 60. More men than women get it. No one knows what causes ALS. It can run in families, but usually it strikes at random. There is no cure. Medicines can relieve symptoms and, sometimes, prolong survival.

NIH: National Institute of Neurological Disorders and Stroke

Courtesy of MedlinePlus from the National Library of Medicine.

Syndicated Content Details:
Source URL: https://medlineplus.gov/amyotrophiclateralsclerosis.html?utm_source=mplusconnect&utm_medium=service
Source Agency: National Library of Medicine

Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive disease that affects motor neurons, which are specialized nerve cells that control muscle movement. These nerve cells are found in the spinal cord and the brain. In ALS, motor neurons die (atrophy) over time, leading to muscle weakness, a loss of muscle mass, and an inability to control movement.

There are many different types of ALS; these types are distinguished by their signs and symptoms and their genetic cause or lack of clear genetic association. Most people with ALS have a form of the condition that is described as sporadic, which means it occurs in people with no apparent history of the disorder in their family. People with sporadic ALS usually first develop features of the condition in their late fifties or early sixties. A small proportion of people with ALS, estimated at 5 to 10 percent, have a family history of ALS or a related condition called frontotemporal dementia (FTD), which is a progressive brain disorder that affects personality, behavior, and language. The signs and symptoms of familial ALS typically first appear in one's late forties or early fifties. Rarely, people with familial ALS develop symptoms in childhood or their teenage years. These individuals have a rare form of the disorder known as juvenile ALS.

The first signs and symptoms of ALS may be so subtle that they are overlooked. The earliest symptoms include muscle twitching, cramping, stiffness, or weakness. Affected individuals may develop slurred speech (dysarthria) and, later, difficulty chewing or swallowing (dysphagia). Many people with ALS experience malnutrition because of reduced food intake due to dysphagia and an increase in their body's energy demands (metabolism) due to prolonged illness. Muscles become weaker as the disease progresses, and arms and legs begin to look thinner as muscle tissue atrophies. Individuals with ALS eventually lose muscle strength and the ability to walk. Affected individuals eventually become wheelchair-dependent and increasingly require help with personal care and other activities of daily living. Over time, muscle weakness causes affected individuals to lose the use of their hands and arms. Breathing becomes difficult because the muscles of the respiratory system weaken. Most people with ALS die from respiratory failure within 2 to 10 years after the signs and symptoms of ALS first appear; however, disease progression varies widely among affected individuals.

Approximately 20 percent of individuals with ALS also develop FTD. Changes in personality and behavior may make it difficult for affected individuals to interact with others in a socially appropriate manner. Communication skills worsen as the disease progresses. It is unclear how the development of ALS and FTD are related. Individuals who develop both conditions are diagnosed as having ALS-FTD.

A rare form of ALS that often runs in families is known as ALS-parkinsonism-dementia complex (ALS-PDC). This disorder is characterized by the signs and symptoms of ALS, in addition to a pattern of movement abnormalities known as parkinsonism, and a progressive loss of intellectual function (dementia). Signs of parkinsonism include unusually slow movements (bradykinesia), stiffness, and tremors. Affected members of the same family can have different combinations of signs and symptoms.

Courtesy of MedlinePlus from the National Library of Medicine.

Syndicated Content Details:
Source URL: https://medlineplus.gov/genetics/condition/amyotrophic-lateral-sclerosis?utm_source=mplusconnect&utm_medium=service
Source Agency: National Library of Medicine

Contents

  • Treatments & Procedures
  • Providers
  • Locations
  • Areas of Expertise
  • Make an Appointment

Treatments and Procedures Related to Amyotrophic Lateral Sclerosis (ALS)

UAMS providers perform and prescribe a broad range of treatments and procedures, some of which may not be listed below.

  • Swallowing Therapy

Providers Treating Amyotrophic Lateral Sclerosis (ALS)

Note that every provider listed below may not perform or prescribe all treatments or procedures related to Amyotrophic Lateral Sclerosis (ALS). Review each provider for availability.

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Sukanthi Kovvuru, M.D.

Sukanthi Kovvuru, M.D. Neuromuscular Medicine Physician (Psychiatry and Neurology)

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Locations Where Providers Treat Amyotrophic Lateral Sclerosis (ALS)

Note that the treatment of Amyotrophic Lateral Sclerosis (ALS) may not be performed at every location listed below. The list may include locations where the treatment plan is developed during and after a patient visit.

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Exterior of Stephens Spine Institute building

Neurology Clinic

501 Jack Stephens Drive
Jackson T. Stephens Spine and Neuroscience Institute
Little Rock, AR 72205

Appointment Phone Number
501-686-5838
New and Returning Patients
View Location Get Directions

Areas of Expertise for Amyotrophic Lateral Sclerosis (ALS)

Portrait of a senior African American couple outdoors. The man is sitting in a wheelchair.

Neurology

UAMS Health provides expert care for adult patients with neurological disorders, including disorders of the brain, spinal cord, peripheral nerves, and muscles.

View Area of Expertise

Make an Appointment

Request an appointment by contacting a clinic directly or by calling the UAMS Health appointment line at (501) 686-8000.

UAMS Health LogoUAMS HealthUniversity of Arkansas for Medical Sciences
Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
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