LITTLE ROCK – Researchers at the
The research team, led by Larry J. Suva, Ph.D., detected proteins in the blood serum of 58 postmenopausal women that signaled increased bone loss. The findings are reported in the June issue of the Journal of Bone and Mineral Research and in the July issue of Nature Clinical Practice – Endocrinology and Metabolism.
“The potential is that we can use a drop of a patient’s blood to diagnose their risk of fracture, their bone turnover and their osteoporosis,” said
Identifying the biomarkers associated with bone loss may someday be used in addition to bone mineral density tests, which often can’t predict the risk of fractures related to bone loss. Until UAMS’ breakthrough, biochemical markers of bone turnover have not provided the specific information needed to make accurate diagnoses of osteoporosis.
“Our findings may lead to a way to potentially supplement the bone density test,”
About 10 million people in the
Researchers used a process called surface-enhanced laser desorption ionization time-of-flight mass spectrometry to search for serum biomarker patterns associated with bone loss. Mass spectrometry is a technique that identifies the chemical composition of a substance.
“We have much more work to do to get this into doctors’ clinics, but it’s exciting that we at UAMS have the technology to interrogate the serum proteome of patients who have diseases other than malignant disease, which is where this technology has been focused in the past,” Suva said.
The research is continuing in collaboration with
UAMS is the state’s only comprehensive academic health center, with five colleges, a graduate school, a medical center, six centers of excellence and a statewide network of regional centers. UAMS has 2,538 students and 733 medical residents. Its centers of excellence include the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute for Research and Therapy, the
UAMS is the state’s only comprehensive academic health center, with colleges of Medicine, Nursing, Pharmacy, Health Professions and Public Health; a graduate school; a hospital; a northwest Arkansas regional campus; a statewide network of regional centers; and seven institutes: the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute, the Harvey & Bernice Jones Eye Institute, the Psychiatric Research Institute, the Donald W. Reynolds Institute on Aging and the Translational Research Institute. It is the only adult Level 1 trauma center in the state. UAMS has 3,021 students, 789 medical residents and two dental residents. It is the state’s largest public employer with more than 10,000 employees, including about 1,000 physicians and other professionals who provide care to patients at UAMS, Arkansas Children’s Hospital, the VA Medical Center and UAMS regional centers throughout the state. Visit www.uams.edu or www.uamshealth.com. Find us on Facebook, Twitter, YouTube or Instagram.